Acute myeloid leukaemia

Active Ingredient: Etoposide

Indication for Etoposide

Population group: only children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Etoposide is indicated in combination with other approved chemotherapeutic agents for the treatment of acute myeloid leukaemia in adult and paediatric patients.

For this indication, competent medicine agencies globally authorize below treatments:

75-150 mg/m²/day once a day for 2-5 days every 3-4 weeks

Route of admnistration

Intravenous

Defined daily dose

75 - 150 mg per m² of body surface area (BSA)

Dosage regimen

From 75 To 150 mg per m² of body surface area (BSA) once every day for 5 day(s)

Detailed description

Etoposide in paediatric patients has been used in the range of 75 to 150 mg/m²/day (etoposide equivalent) for 2 to 5 days in combination with other antineoplastic agents. The treatment regimen should be chosen according to the local standard of care.

Dosage considerations

Etoposide phosphate is administered by slow intravenous infusion (usually over a 30 to 60 minute period).

Active ingredient

Etoposide

The main effect of etoposide appears to be at the late S and early G2 portion of the cell cycle in mammalian cells. The predominant macromolecular effect of etoposide seems to be the rupture of the double strand by an interaction with DNA-topoisomerase II or by the formation of free radicals. Etoposide has been shown to cause metaphase arrest in chick fibroblasts.

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