VEPESID Capsule, soft Ref.[8156] Active ingredients: Etoposide

Source: Medicines & Healthcare Products Regulatory Agency (GB)  Revision Year: 2019  Publisher: CHEPLAPHARM Arzneimittel GmbH, Ziegelhof 24, 17489, Greifswald, Germany

Product name and form

VEPESID 50 mg capsule, soft.

Pharmaceutical Form

Capsule, Soft.

Opaque pink.

Qualitative and quantitative composition

Each capsule contains 50 mg etoposide.

Excipients with known effect:

Each 50 mg capsule, soft contains:

  • 0.93 mg of sodium ethyl parahydroxybenzoate (E215) and
  • 0.47 mg of sodium propyl parahydroxybenzoate (E217).

For the full list of excipients, see section 6.1.

Active Ingredient Description
Etoposide

The main effect of etoposide appears to be at the late S and early G2 portion of the cell cycle in mammalian cells. The predominant macromolecular effect of etoposide seems to be the rupture of the double strand by an interaction with DNA-topoisomerase II or by the formation of free radicals. Etoposide has been shown to cause metaphase arrest in chick fibroblasts.

List of Excipients

Capsule content:

Citric acid, anhydrous (E330)
Macrogol 400 (E1521)
Glycerol (85 per cent) (E422)
Water, purified

Capsule shell:

Glycerol (85 per cent) (E422)
Gelatin (E441)
Sodium ethyl parahydroxybenzoate (E215)
Sodium propyl parahydroxybenzoate (E217)
Titanium dioxide (E171)
Red iron oxide (E172)

Pack sizes and marketing

Pack of 20, 50 Capsules, softgels.

Not all pack sizes may be marketed.

Marketing authorization holder

CHEPLAPHARM Arzneimittel GmbH, Ziegelhof 24, 17489, Greifswald, Germany

Marketing authorization dates and numbers

PL 27041/0016

29 April 1983 / 18 September 2002

Drugs

Drug Countries
VEPESID Austria, Australia, Canada, Estonia, Spain, Finland, Ireland, Japan, Malta, Netherlands, New Zealand, Romania, United Kingdom

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