Active Ingredient: Amiloride
In congestive heart failure, amiloride hydrochloride may be effective alone, but its principal indication is for concomitant use in patients receiving thiazides or more potent diuretic agents.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
2.5 - 10 mg
From 2.5 To 10 mg once every day
Initially 2.5mg a day together with the usual dosage of the diuretic concurrently employed, subsequently adjusted if required, but not exceeding 10mg a day. Optimal dosage is determined by diuretic response and the plasma potassium level. Once an initial diuresis has been achieved, reduction in dosage may be attempted for maintenance therapy. Maintenance therapy may be on an intermittent basis.
The elderly are more susceptible to electrolyte imbalance, and are more likely to experience hyperkalaemia since renal reserve may be reduced. The dosage should be carefully adjusted according to renal function, blood electrolytes and diuretic response.
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