Active Ingredient: Indapamide
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A: Tablet, multiplayer, extended release oral, 1.5 milligrams indapamide, once daily at morning.
Regimen B: Tablet oral, 2.5 milligrams indapamide, once daily at morning.
1.5 mg or 2.5 mg per 24 hours, preferably in the morning.
The action of indapamide is progressive and the reduction in blood pressure may continue and not reach a maximum until several months after the start of therapy. A larger dose than 2.5 mg indapamide daily is not recommended as there is no appreciable additional antihypertensive effect but a diuretic effect may become apparent.
If a single daily tablet of indapamide does not achieve a sufficient reduction in blood pressure, another antihypertensive agent may be added; those which have been used in combination with indapamide include beta-blockers, ACE inhibitors, methyldopa, clonidine and other adrenergic blocking agents. The co-administration of indapamide with diuretics which may cause hypokalaemia is not recommended. There is no evidence of rebound hypertension on withdrawal of indapamide.
In the elderly, the plasma creatinine must be adjusted in relation to age, weight and gender. Elderly patients can be treated with indapamide when renal function is normal or only minimally impaired.
To be taken preferably in the morning.
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