Active Ingredient: Temozolomide
Temozolomide is indicated for the treatment of children from the age of three years, adolescents and adult patients with malignant glioma, such as glioblastoma multiforme or anaplastic astrocytoma, showing recurrence or progression after standard therapy.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
150 - 200 mg per m² of body surface area (BSA)
From 150 To 200 mg per m² of body surface area (BSA) once every day
A treatment cycle comprises 28 days. In patients previously untreated with chemotherapy, temozolomide is administered orally at a dose of 200 mg/m² once daily for the first 5 days followed by a 23 day treatment interruption (total of 28 days). In patients previously treated with chemotherapy, the initial dose is 150 mg/m² once daily, to be increased in the second cycle to 200 mg/m² once daily, for 5 days if there is no haematological toxicity.
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