Chemical formula: C₆H₆N₆O₂ Molecular mass: 194.151 g/mol PubChem compound: 5394
Temozolomide is a triazene, which undergoes rapid chemical conversion at physiologic pH to the active monomethyl triazenoimidazole carboxamide (MTIC). The cytotoxicity of MTIC is thought to be due primarily to alkylation at the O6 position of guanine with additional alkylation also occurring at the N7 position. Cytotoxic lesions that develop subsequently are thought to involve aberrant repair of the methyl adduct.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01AX03 | Temozolomide | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01A Alkylating agents → L01AX Other alkylating agents |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| TEMODAL Hard capsule | European Medicines Agency (EU) | MPI, EU: SmPC | |
| TEMODAL Powder for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC |
Temozolomide is an active ingredient of these brands:
United States (US)Albania (AL)Canada (CA)Israel (IL)Japan (JP)Mexico (MX)Netherlands (NL)New Zealand (NZ)Romania (RO)Spain (ES)Tunisia (TN)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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