Acute lymphoblastic leukaemia (ALL)

Active Ingredient: Asparaginase

Indication for Asparaginase

Population group: only infants (40 days - 1 year old)

Asparaginase is indicated as a component of antineoplastic combination therapy for the treatment of acute lymphoblastic leukaemia (ALL) in paediatric patients from birth to 18 years and adults.

For this indication, competent medicine agencies globally authorize below treatments:

6700-7500 U/m² every third day

Route of admnistration

Intravenous

Defined daily dose

6,700 - 7,500 [iU] per m² of body surface area (BSA)

Dosage regimen

From 6,700 To 7,500 [iU] per m² of body surface area (BSA) once every 3 day(s)

Detailed description

Asparaginase is usually employed as part of combination chemotherapy protocols with other antineoplastic agents.

Based on limited data, the recommended dose in infants is as follows:

  • age less than 6 months: 6,700 U/m² BSA,
  • age 6–12 months: 7,500 U/m² BSA.

Dosage considerations

The diluted solution of asparaginase may be infused over 0.5 to 2 hours.

Active ingredient

Asparaginase

Asparaginase hydrolyses asparagine to aspartic acid and ammonia. In contrast to normal cells, lymphoblastic tumour cells have a very limited capacity for synthesising asparagine because of a significantly reduced expression of asparagine synthetase. Therefore, they require asparagine which diffuses from the extracellular environment. As a result of asparaginase-induced asparagine depletion in serum, protein synthesis in lymphoblastic tumour cells is disturbed while sparing most normal cells.

Read more about Asparaginase

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