Chemical formula: C₁₃₇₇H₂₂₀₈N₃₈₂O₄₄₂S₁₇ PubChem compound: 5460875
Asparaginase hydrolyses asparagine to aspartic acid and ammonia. In contrast to normal cells, lymphoblastic tumour cells have a very limited capacity for synthesising asparagine because of a significantly reduced expression of asparagine synthetase. Therefore, they require asparagine which diffuses from the extracellular environment. As a result of asparaginase-induced asparagine depletion in serum, protein synthesis in lymphoblastic tumour cells is disturbed while sparing most normal cells.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| L01XX02 | Asparaginase | L Antineoplastic and immunomodulating agents → L01 Antineoplastic agents → L01X Other antineoplastic agents → L01XX Other antineoplastic agents |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| SPECTRILA Powder for concentrate for solution for infusion | European Medicines Agency (EU) | MPI, EU: SmPC |
Asparaginase is an active ingredient of these brands:
United States (US)Brazil (BR)
Finland (FI)
Hong Kong (HK)
Japan (JP)
Malta (MT)Mexico (MX)
Romania (RO)
Singapore (SG)
South Africa (ZA)Turkey (TR)
Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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