Active Ingredient: Carvedilol
Carvedilol is indicated to reduce cardiovascular mortality in clinically stable patients who have survived the acute phase of a myocardial infarction and have a left ventricular ejection fraction of less than or equal to 40% (with or without symptomatic heart failure).
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 6.25 milligrams carvedilol, 2 times daily to meals, over the duration of 3 to 10 days. Afterwards, oral, 12.5 milligrams carvedilol, 2 times daily to meals, over the duration of 3 to 10 days. Afterwards, oral, 25 milligrams carvedilol, 2 times daily to meals. The maximum allowed total dose is 50 milligrams carvedilol daily.
DOSAGE MUST BE INDIVIDUALIZED AND MONITORED DURING UP-TITRATION. Treatment with carvedilol may be started as an inpatient or outpatient and should be started after the patient is hemodynamically stable and fluid retention has been minimized.
It is recommended that carvedilol be started at 6.25 mg twice daily and increased after 3 to 10 days, based on tolerability, to 12.5 mg twice daily, then again to the target dose of 25 mg twice daily. A lower starting dose may be used (3.125 mg twice daily) and/or the rate of up-titration may be slowed if clinically indicated (e.g., due to low blood pressure or heart rate, or fluid retention). Patients should be maintained on lower doses if higher doses are not tolerated. The recommended dosing regimen need not be altered in patients who received treatment with an IV or oral β-blocker during the acute phase of the myocardial infarction.
It should be taken with food to slow the rate of absorption and reduce the incidence of orthostatic effects.
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