Hodgkin's disease

Active Ingredient: Lomustine

Indication for Lomustine

Population group: only adults (18 years old or older)

Hodgkin’s disease (resistant to conventional combination chemotherapy).

For this indication, competent medicine agencies globally authorize below treatments:

120-130 mg/m² once every 6-8 weeks

Route of admnistration

Oral

Defined daily dose

120 - 130 mg per m² of body surface area (BSA)

Dosage regimen

From 120 To 130 mg per m² of body surface area (BSA) once every 42 day(s) for 1 day(s)

Detailed description

Lomustine is given by mouth. The recommended dose in patients with normally functioning bone marrow receiving lomustine as their only chemotherapy is 120–130 mg/m² as a single dose every six to eight weeks (or as a divided dose over 3 days, e.g. 40 mg/m²/day).

Dosage is reduced:

  • if lomustine is given as part of a drug regimen which includes other marrow-depressant medicinal products.
  • in the presence of leucopenia below 3,000/mm³ or thrombocytopenia below 75,000/mm³.

Marrow depression after lomustine is sustained longer than after nitrogen mustards and recovery of white cell and platelet counts may not occur for six weeks or more. Blood elements depressed below the above levels should be allowed to recover to 4,000/mm³ (WBC) and 100,000/mm³ (platelets) before repeating lomustine dosage.

Active ingredient

Lomustine

Lomustine’s mode of action is believed to be partly as an alkylating agent and partly by inhibition of several steps in the synthesis of nucleic acid and inhibition of the repair of single strand breaks in DNA chains.

Read more about Lomustine

Related medicines

Summary of Product Characteristics (SPC) 2019: LOMUSTINE MEDAC Capsule

Develop a tailored medication plan for your case, considering factors such as age, gender, and health history

Ask the Reasoner

Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.

⇈