Active Ingredient: Iloperidone
Acute treatment of manic or mixed episodes associated with bipolar I disorder in adults.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, 1 milligrams iloperidone, 2 times daily, over the duration of 1 day. Afterwards, oral, 3 milligrams iloperidone, 2 times daily, over the duration of 1 day. Afterwards, oral, 6 milligrams iloperidone, 2 times daily, over the duration of 1 day. Afterwards, oral, 9 milligrams iloperidone, 2 times daily, over the duration of 1 day. Afterwards, oral, 12 milligrams iloperidone, 2 times daily.
Titrate iloperidone to avoid orthostatic hypotension. The table below includes dosage recommendations for iloperidone for the acute treatment of manic or mixed episodes associated with bipolar I disorder in adults.
Dosage recommendations for iloperidone in adults for the acute treatment of manic or mixed episodes associated with bipolar I disorder:
| Indication and population | Titration schedule | Recommended dosage | ||||||
|---|---|---|---|---|---|---|---|---|
| Day 1 | Day 2 | Day 3 | Day 4 | Day 5 | Day 6 | Day 7 | ||
| Bipolar I disorder manic or mixed episodes | 1 mg twice daily | 3 mg twice daily | 6 mg twice daily | 9 mg twice daily | 12 mg twice daily | Titration complete | 12 mg twice daily | |
Although there are no data to specifically address reinitiation of treatment, it is recommended that the initiation titration schedule be followed whenever patients have had an interval off iloperidone of more than 3 days.
Administer iloperidone orally with or without food.
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