Active Ingredient: Botulinum toxin type A
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intramuscular, 20 international units botulinum toxin type A, once every 3 months.
Recommended needle: Sterile 30 gauge needle.
Administration guidance:
To identify the location of the appropriate injection sites in the frontalis muscle, assess the overall relationship between the size of the subject’s forehead, and the distribution of frontalis muscle activity should be assessed.
The following horizontal treatment rows should be located by light palpation of the forehead at rest and maximum eyebrow elevation:
The 5 injections should be placed at the intersection of the horizontal treatment rows with the following vertical landmarks:
Figure:
Care should be taken to ensure that botulinum toxin type A is not injected into a blood vessel when it is injected in the forehead lines seen at maximum eyebrow elevation.
Recommended dose:
A volume of 0.1 ml (4 Units) is administered in each of the 5 injection sites in the frontalis muscle, for a total dose of 20 Units in a total volume of 0.5 ml (see Figure).
The total dose for treatment of forehead lines (20 Units) in conjunction with glabellar lines (20 Units) is 40 Units/1.0 mL.
For simultaneous treatment with glabellar lines and crow’s feet lines, the total dose is 64 Units, comprised of 20 Units for forehead lines, 20 Units for glabellar lines, and 24 Units for crow’s feet lines.
Additional information: Treatment intervals should not be more frequent than every 3 months.
The efficacy and safety of repeat injections of botulinum toxin type A for the treatment of forehead lines beyond 12 months has not been evaluated.
Liability Disclaimer : RxReasoner has utilized reasonable care in providing content and services that are accurate, complete and up to date. However, RxReasoner does not accept any responsibility or liability about it. The content and services of RxReasoner are for informational purposes only and they are not intended to be a substitute for the knowledge, expertise, skill, and judgment of physicians, pharmacists, nurses, or other healthcare professionals involved in patient care. RxReasoner offers no medical advice. Users are responsible for the use of the provided content. A shown indication or treatment should not be construed to indicate that the medication is safe, appropriate, or effective in any given patient or under any particular circumstances. The absence of an indication or treatment should not roule out the existence of other appropriate medications. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition or medicament. RxReasoner is not liable for any damages allegedly sustained arising out of the use of its content and services.
