Active Ingredient: Zanamivir
Zanamivir is indicated for post-exposure prophylaxis of influenza A and B in adults and children (≥5 years) following contact with a clinically diagnosed case in a household. In exceptional circumstances, zanamivir may be considered for seasonal prophylaxis of influenza A and B during a community outbreak (e.g. in case of a mismatch between circulating and vaccine strains and a pandemic situation).
Zanamivir is not a substitute for influenza vaccination. The appropriate use of zanamivir for prevention of influenza should be determined on a case-by-case basis depending on the circumstances and the population requiring protection.
The use of antivirals for the treatment and prevention of influenza should take into consideration official recommendations, the variability of epidemiology, and the impact of the disease in different geographical areas and patient populations.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Regimen A: In case that patient age in years is ≥ 5 and there is exposure to Influenzavirus, respiratory (Inhalation), 10 milligrams zanamivir, once daily, over the duration of 10 days.
Regimen B: In case that patient age in years is ≥ 5, respiratory (Inhalation), 10 milligrams zanamivir, once daily, over the duration of 28 days.
The recommended dose of zanamivir for prevention of influenza, following close contact with an individual, is 10 mg once daily for 10 days. Therapy should begin as soon as possible and within 36 hours of exposure to an infected person.
The recommended dose of zanamivir for prevention of influenza during a community outbreak is 10 mg once daily for up to 28 days.
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