Active Ingredient: Alitretinoin
Alitretinoin is indicated for use in adults who have severe chronic hand eczema that is unresponsive to treatment with potent topical corticosteroids.
Patients in whom the eczema has predominantly hyperkeratotic features are more likely to respond to treatment than in those in whom the eczema predominantly presents as pompholyx.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
10 - 30 mg
From 10 To 30 mg once every day
30 mg
The recommended dose for alitretinoin is 10 mg or 30 mg once daily.
The recommended starting dose for alitretinoin is 30 mg once daily. A dose reduction to 10 mg once daily may be considered in patients with unacceptable adverse reactions to the 30 mg dose. In studies investigating 10 mg and 30 mg daily doses, both doses resulted in clearing of the disease. The 30 mg dose provided a more rapid response and a higher response rate. The 10 mg daily dose was associated with fewer adverse events.
A treatment course of alitretinoin may be given for 12 to 24 weeks depending on response. Discontinuation of therapy is recommended in patients who have achieved clear or almost clear hands earlier than 24 weeks. Discontinuation of therapy should also be considered for patients who still have severe disease after the initial 12 weeks of continuous treatment.
In the event of relapse, patients may benefit from further treatment courses of alitretinoin.
Alitretinoin should be taken with a main meal once daily, preferably at the same time each day.
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