Cluster headache episodes

Active Ingredient: Dihydroergotamine

Indication for Dihydroergotamine

Population group: only adults (18 - 65 years old)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

1 ml that can be repeated at 1 hour intervals

For:

Dosage regimens

Regimen A: Intravenous, 1 milliliters dihydroergotamine, once hourly, 1 to 2 doses in total.

Regimen B: Intramuscular, 1 milliliters dihydroergotamine, once hourly, 1 to 3 doses in total.

Regimen C: Subcutaneous, 1 milliliters dihydroergotamine, once hourly, 1 to 3 doses in total.

Detailed description

Dihydroergotamine should be administered in a dose of 1 mL intravenously, intramuscularly or subcutaneously. The dose can be repeated, as needed, at 1 hour intervals to a total dose of 3 mL for intramuscular or subcutaneous delivery or 2 mL for intravenous delivery in a 24 hour period. The total weekly dosage should not exceed 6 mL.

Dihydroergotamine mesylate should not be used for chronic daily administration.

Active ingredient

Dihydroergotamine

Dihydroergotamine binds with high affinity to 5-HT1DĪ± and 5-HT1DĪ² receptors. It also binds with high affinity to serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors. The therapeutic activity of dihydroergotamine in migraine is generally attributed to the agonist effect at 5-HT1D receptors.

Read more about Dihydroergotamine

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