Active Ingredient: Desmopressin
To increase Factor VIII:C and Factor VIII:Ag in patients with mild to moderate haemophilia or von Willebrand’s disease undergoing surgery or following trauma.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Intravenous, 0.4 micrograms desmopressin per kilogram of body weight, once every 12 hours.
The dose for adults, children and infants is 0.4 micrograms per kilogram body weight administered by intravenous infusion. Further doses may be administered at 12 hourly intervals so long as cover is required. As some patients have shown a diminishing response to successive doses, it is recommended that monitoring of Factor VIII levels should continue. The dose should be diluted in 50ml of 0.9% sodium chloride for injection and given over 20 minutes. This dose should be given immediately prior to surgery or following trauma. During administration of intravenous desmopressin, vasodilation may occur resulting in decreased blood pressure and tachycardia with facial flushing in some patients.
Increase of Factor VIII levels are dependent on basal levels and are normally between 2 and 5 times the pre-treatment levels. If results from a previous administration of desmopressin are not available then blood should be taken pre-dose and 20 minutes post-dose for assay of Factor VIII levels in order to monitor response.
Unless contraindicated, when surgery is undertaken, tranexamic acid may be given orally at the recommended dose from 24 hours beforehand until healing is complete.
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