Active Ingredient: Captopril
Captopril is indicated for the treatment of macroproteinuric diabetic nephropathy in patients with type I diabetes.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
6.25 - 100 mg
From 3.125 To 50 mg 2 time(s) per day every day
The recommended starting dose is 25-50 mg daily in two divided doses. The dose may be increased incrementally, with intervals of at least 2 weeks, to 100-150 mg/day in two divided doses as needed to reach target blood pressure. Captopril may be used alone or with other antihypertensive agents, especially thiazide diuretics. A once-daily dosing regimen may be appropriate when concomitant antihypertensive medication such as thiazide diuretics is added.
In patients with a strongly active renin-angiotensin-aldosterone system (hypovolaemia, renovascular hypertension, cardiac decompensation) it is preferable to commence with a single dose of 6.25 mg or 12.5 mg. The inauguration of this treatment should preferably take place under close medical supervision. These doses will then be administered at a rate of two per day. The dosage can be gradually increased to 50mg per day in one or two doses and if necessary to 100 mg per day in one or two doses.
As with other antihypertensive agents, consideration should be given to initiating therapy with a lower starting dose (6.25 mg BID) in elderly patients who may have reduced renal function and other organ dysfunctions.
Dosage should be titrated against the blood pressure response and kept as low as possible to achieve adequate control.
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