Chemical formula: C₉H₁₅NO₃S Molecular mass: 217.285 g/mol PubChem compound: 44093
Captopril is a highly specific, competitive inhibitor of angiotensin-I converting enzyme (ACE inhibitors). Inhibition of ACE results in decreased plasma angiotensin-II, which leads to decreased vasopressor activity and to reduced aldosterone secretion. In patients with hypertension, captopril causes a reduction in supine and erect blood pressure, without inducing any compensatory increase in heart rate, nor water and sodium retention.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C09AA01 | Captopril | C Cardiovascular system → C09 Agents acting on the renin-angiotensin system → C09A ACE inhibitors, plain → C09AA ACE inhibitors, plain |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| CAPOTEN Tablets | Medicines & Healthcare Products Regulatory Agency (GB) | MPI, EU: SmPC |
Captopril is an active ingredient of these brands:
Australia (AU)Brazil (BR)France (FR)Germany (DE)
Ireland (IE)Israel (IL)Lithuania (LT)Malta (MT)Mexico (MX)
New Zealand (NZ)South Africa (ZA)
Spain (ES)
Tunisia (TN)United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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