Active Ingredient: Fluticasone
Fluticasone propionate given by inhalation offers prophylactic treatment for asthma.
Mild asthma: Patients requiring intermittent symptomatic bronchodilator asthma medication on a regular daily basis.
Moderate asthma: Patients with unstable or worsening asthma despite prophylactic therapy or bronchodilator alone.
Severe asthma: Patients with severe chronic asthma and those who are dependent on systemic corticosteroids for adequate control of symptoms. On introduction of inhaled fluticasone propionate many of these patients may be able to reduce significantly, or to eliminate, their requirement for oral corticosteroids.
For this indication, competent medicine agencies globally authorize below treatments:
Respiratory (Inhalation)
200 - 2,000 ug
From 100 To 1,000 ug 2 time(s) per day every day
100 to 1,000 micrograms twice daily, usually as two twice daily inhalations.
Prescribers should be aware that fluticasone propionate is as effective as other inhaled steroids approximately at half the microgram daily dose. For example, a 100mcg of fluticasone propionate is approximately equivalent to 200mcg dose of beclometasone dipropionate (CFC containing) or budesonide.
Due to the risk of systemic effects, doses above 500 micrograms twice daily should be prescribed only for adult patients with severe asthma where additional clinical benefit is expected, demonstrated by either an improvement in pulmonary function and/or symptom control, or by a reduction in oral corticosteroid therapy.
Patients should be given a starting dose of inhaled fluticasone propionate which is appropriate to the severity of their disease.
The dose may be increased until control is achieved or reduced to the minimum effective dose, according to the individual response.
For patients with mild asthma, a typical starting dose is 100 micrograms twice daily. In moderate and more severe asthma, starting doses may need to be 250 to 500 micrograms twice daily. Where additional clinical benefit is expected, doses of up to 1000 micrograms twice daily may be used. Initiation of such doses should be prescribed only by a specialist in the management of asthma (such as a consultant physician or general practitioner with appropriate experience).
The dose should be titrated down to the lowest dose at which effective control of asthma is maintained
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