Headache phase of migraine attacks

Active Ingredient: Lasmiditan

Indication for Lasmiditan

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

Lasmiditan is indicated for the acute treatment of the headache phase of migraine attacks, with or without aura in adults.

For this indication, competent medicine agencies globally authorize below treatments:

50-200 mg once

For:

Dosage regimens

Oral, between 50 milligrams lasmiditan and 200 milligrams lasmiditan, one dose.

Detailed description

In general, recommended initial dose in adults is 100 mg lasmiditan for acute treatment of migraine attacks. If necessary, the dose can be increased to 200 mg for greater efficacy or can be decreased to 50 mg for greater tolerability.

If the migraine headache recurs within 24 hours of an initial response after taking 50 mg or 100 mg lasmiditan, a second dose of the same strength may be taken. The second dose should not be taken within 2 hours of the initial dose.

No more than 200 mg should be taken in 24 hours.

If a patient does not respond to the first dose, it is unlikely that a second dose will be of benefit in the same attack.

Dosage considerations

Lasmiditan may be taken with or without food.

Active ingredient

Lasmiditan

Lasmiditan is a high affinity, centrally-penetrant, 5-hydroxytriptamine 1F (5-HT1F) receptor agonist. The precise mechanism of action is unknown, however, the therapeutic effects of lasmiditan in the treatment of migraine presumably involve agonistic effects at the 5-HT1F receptor, a decrease of neuropeptide release and an inhibition of pain pathways, including the trigeminal nerve.

Read more about Lasmiditan

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