Bladder pain syndrome

Active Ingredient: Pentosan polysulfate

Indication for Pentosan polysulfate

Population group: only adults (18 - 65 years old)

Pentosan polysulfate sodium is indicated for the treatment of bladder pain syndrome characterized by either glomerulations or Hunner’s lesions in adults with moderate to severe pain, urgency and frequency of micturition.

For this indication, competent medicine agencies globally authorize below treatments:

300 mg in 3 divided doses daily

Route of admnistration

Oral

Defined daily dose

300 - 300 mg

Dosage regimen

From 100 To 100 mg 3 time(s) per day every day

Detailed description

The recommended dose of pentosan polysulfate sodium is 300 mg/day taken as one 100 mg capsule orally three times daily.

Response to treatment with pentosan polysulfate sodium should be reassessed every 6 months. In case no improvement is reached 6 months after treatment initiation, treatment with pentosan polysulfate sodium should be stopped. In responders pentosan polysulfate sodium treatment should be continued chronically as long as the response is maintained.

Dosage considerations

It should be taken with water at least 1 hour before meals or 2 hours after meals.

Active ingredient

Pentosan polysulfate

The hypothetic mechanism of action of pentosan polysulfate includes a local effect in the bladder after systemic administration and excretion into the urine by binding of glycosaminoglycans to the deficient mucous of the bladder. It is hypothesized, that a potential barrier function of pentosan polysulfate instead of the damaged urothelial mucus might play a role as well the antiinflammatory activity of pentosan polysulfate sodium.

Read more about Pentosan polysulfate

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