Chemical formula: C₁₀H₁₈O₂₁S₄ Molecular mass: 602.497 g/mol PubChem compound: 37720
The hypothetic mechanism of action of pentosan polysulfate includes a local effect in the bladder after systemic administration and excretion into the urine by binding of glycosaminoglycans to the deficient mucous of the bladder. It is hypothesized, that a potential barrier function of pentosan polysulfate instead of the damaged urothelial mucus might play a role as well the antiinflammatory activity of pentosan polysulfate sodium.
This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:
| ATC code | Group title | Classification |
|---|---|---|
| C05BA04 | Pentosan polysulfate sodium | C Cardiovascular system → C05 Vasoprotectives → C05B Antivaricose therapy → C05BA Heparins or heparinoids for topical use |
| G04BX15 | Pentosan polysulfate sodium | G Genito urinary system and sex hormones → G04 Urologicals → G04B Other urologicals, incl. antispasmodics → G04BX Other urologicals |
Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):
| Title | Information Source | Document Type | |
|---|---|---|---|
| ELMIRON Hard capsule | European Medicines Agency (EU) | MPI, EU: SmPC |
Pentosan polysulfate is an active ingredient of these brands:
United States (US)Austria (AT)Canada (CA)Croatia (HR)Estonia (EE)France (FR)Hong Kong (HK)
Ireland (IE)Italy (IT)Lithuania (LT)Netherlands (NL)Poland (PL)Spain (ES)
United Kingdom (UK)Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide. |
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