Active Ingredient: Sotalol
Ventricular arrhythmias:
For this indication, competent medicine agencies globally authorize below treatments:
Oral
80 - 640 mg
From 40 To 320 mg 2 time(s) per day every day
80 mg
The following dosing schedule can be recommended:
The initial dose is 80 mg, administered either singly or as two divided doses.
Oral dosage of sotalol should be adjusted gradually allowing 2-3 days between dosing increments in order to attain steady-state, and to allow monitoring of QT intervals. Most patients respond to a daily dose of 160 to 320 mg administered in two divided doses at approximately 12 hour intervals. Some patients with life-threatening refractory ventricular arrhythmias may require doses as high as 480-640 mg/day. These doses should be used under specialist supervision and should only be prescribed when the potential benefit outweighs the increased risk of adverse events, particularly proarrhythmias.
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