Active Ingredient: Ibuprofen
For relief of the signs and symptoms of rheumatoid arthritis.
For this indication, competent medicine agencies globally authorize below treatments:
For:
Oral, between 1,200 milligrams ibuprofen and 3,200 milligrams ibuprofen, divided daily, 3 to 4 doses in total. The maximum allowed total dose is 3,200 milligrams ibuprofen daily.
1,200 mg – 3,200 mg daily (400 mg, 600 mg or 800 mg tid or qid).
Individual patients may show a better response to 3,200 mg daily, as compared with 2,400 mg, although in well-controlled clinical trials patients on 3,200 mg did not show a better mean response in terms of efficacy. Therefore, when treating patients with 3,200 mg/day, the physician should observe sufficient increased clinical benefits to offset potential increased risk. The dose should be tailored to each patient, and may be lowered or raised depending on the severity of symptoms either at time of initiating drug therapy or as the patient responds or fails to respond.
The smallest dose of ibuprofen that yields acceptable control should be employed. A linear blood level dose-response relationship exists with single doses up to 800 mg.
It is recommended that patients with sensitive stomachs take ibuprofen tablet with food. If taken shortly after eating, the onset of action of ibuprofen tablet may be delayed. To be taken preferably with or after food, with plenty of fluid.
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