Active Ingredient: Mefloquine
Malaria chemoprophylaxis with Lariam is particularly recommended for travellers to malarious areas in which multiply resistant P. falciparum strains occur.
For this indication, competent medicine agencies globally authorize below treatments:
Oral
5 - 5 mg per kg of body weight
From 5 To 5 mg per kg of body weight once every 7 day(s)
For malaria prophylaxis the stated dose of mefloquine should be given once weekly, always on the same day.
In order to ensure, before arrival in endemic area, that mefloquine administration is well tolerated, it is recommended to start chemoprophylaxis with mefloquine 10 days before departure (i.e. first intake 10 days before departure and 2nd intake 3 days before departure). Subsequent doses should be taken once a week (on a fixed day).
Treatment should be continued for 4 weeks after leaving a malarious area (minimum treatment period 6 weeks). The maximum recommended duration of administration of mefloquine is 12 months.
The recommended chemoprophylactic dose of mefloquine is approximately 5 mg/kg bodyweight once weekly. The following dosage schedule is given as a guide:
| Dosage | |
|---|---|
| Adults and children of more than 45 kg bodyweight | 1 tablet |
| Children and adults weighing less than 45 kg | |
| 5–19 kg | ¼ tablet |
| 20–30 kg | ½ tablet |
| 31–45 kg | ¾ tablet |
It should be swallowed whole preferably after a meal with plenty of liquid.
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