Active Ingredient: Bleomycin
For this indication, competent medicine agencies globally authorize below treatments:
Intramuscular
10,000 - 15,000 [iU] per m² of body surface area (BSA)
From 10,000 To 15,000 [iU] per m² of body surface area (BSA) once every 7 day(s)
Intramuscular or intravenous injection of 10-15 × 103 IU/m² body surface area (BSA), once or twice a week, at intervals of 3-4 weeks up to a lifetime cumulative dose of 400 × 103 IU.
Dissolve the contents of a vial in 1-5 mL physiological saline solution. Since repeated i.m. injections at the same site can cause local discomfort, it is recommended to change the injection site regularly. In the event of excessive local discomfort, a local anaesthetic can be added to the injection solution, e.g. 1.5-2 mL lidocaine HCl 1%.
Intravenous
10,000 - 15,000 [iU] per m² of body surface area (BSA)
From 10,000 To 15,000 [iU] per m² of body surface area (BSA) once every 7 day(s)
Intramuscular or intravenous injection of 10-15 × 103 IU/m² body surface area (BSA), once or twice a week, at intervals of 3-4 weeks up to a lifetime cumulative dose of 400 × 103 IU.
Dissolve the contents of a vial in 5-10 mL physiological saline solution and inject slowly over a period of 5-10 minutes. Fast bolus injections are to be avoided, because they lead to high intrapulmonary plasma concentrations, increasing the risk of lung damage.
Dissolve the contents of a vial in 200-1,000 mL physiological saline solution.
Intravenous
10,000 - 15,000 [iU] per m² of body surface area (BSA)
From 10,000 To 15,000 [iU] per m² of body surface area (BSA) once every day for 5 day(s)
The intravenous infusion of the dose of 10-15 × 103 IU/m² BSA/day is performed for 6-24 hours on 5-6 consecutive days, at intervals of 3-4 weeks.
Dissolve the contents of a vial in 5-10 mL physiological saline solution and inject slowly over a period of 5-10 minutes. Fast bolus injections are to be avoided, because they lead to high intrapulmonary plasma concentrations, increasing the risk of lung damage.
Dissolve the contents of a vial in 200-1,000 mL physiological saline solution.
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