Prolonged, acute, convulsive seizures

Active Ingredient: Midazolam

Indication for Midazolam

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Treatment of prolonged, acute, convulsive seizures in infants, toddlers, children and adolescents (from 3 months to <18 years).

For this indication, competent medicine agencies globally authorize below treatments:

2.5-10.0 mg

Route of admnistration

Oral

Defined daily dose

2.5 - 10 mg

Dosage regimen

From 2.5 To 10 mg once every day

Detailed description

Standard doses are indicated below:

Age rangeDose
3 to 6 months hospital setting2.5 mg
> 6 months to < 1 year2.5 mg
1 year to < 5 years5 mg
5 years to < 10 years7.5 mg
10 years to < 18 years10 mg

Carers should only administer a single dose of midazolam. If the seizure has not stopped within 10 minutes after administration of midazolam, emergency medical assistance must be sought and the empty syringe given to the healthcare professional to provide information on the dose received by the patient.

A second or repeat dose when seizures re-occur after an initial response should not be given without prior medical advice.

Dosage considerations

Midazolam is for oromucosal use. The full amount of solution should be inserted slowly into the space between the gum and the cheek. Laryngo-tracheal insertion should be avoided to prevent accidental aspiration of the solution. If necessary (for larger volumes and/or smaller patients), approximately half the dose should be given slowly into one side of the mouth, then the other half given slowly into the other side.

Active ingredient

Midazolam

Midazolam is a derivative of the imidazobenzodiazepine group. The free base is a lipophilic substance with low solubility in water. The basic nitrogen in position 2 of the imidazobenzodiazepine ring system enables the active ingredient of midazolam to form water-soluble salts with acids.

Read more about Midazolam

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