Active Ingredient: Rotigotine
Rotigotine is indicated for the treatment of the signs and symptoms of early-stage idiopathic Parkinson’s disease as monotherapy (i.e. without levodopa).
For this indication, competent medicine agencies globally authorize below treatments:
For:
Transdermal, 2 milligrams rotigotine, daily, over the duration of 1 week. Afterwards, transdermal, 4 milligrams rotigotine, daily, over the duration of 1 week. Afterwards, transdermal, 6 milligrams rotigotine, daily, over the duration of 1 week. Afterwards, transdermal, 8 milligrams rotigotine, daily. The maximum allowed total dose is 8 milligrams rotigotine daily.
A single daily dose should be initiated at 2 mg/24 h and then increased in weekly increments of 2 mg/24 h to an effective dose up to a maximum dose of 8 mg/24 h. 4 mg/24 h may be an effective dose in some patients. For most patients an effective dose is reached within 3 or 4 weeks at doses of 6 mg/24 h or 8 mg/24 h, respectively.
The maximum dose is 8 mg/24 h.
Rotigotine should be discontinued gradually. The daily dose should be reduced in steps of 2 mg/24 h with a dose reduction preferably every other day, until complete withdrawal of rotigotine.
The patch should be applied to clean, dry, intact healthy skin on the abdomen, thigh, hip, flank, shoulder, or upper arm. Reapplication to the same site within 14 days should be avoided. The patch should not be placed on skin that is red, irritated or damaged.
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