Rheumatoid arthritis

Active Ingredient: Methotrexate

Indication for Methotrexate

Population group: only adults (18 years old or older)

Active rheumatoid arthritis in adult patients.

For this indication, competent medicine agencies globally authorize below treatments:

7.5-20 mg once weekly

Route of admnistration

Oral

Defined daily dose

7.5 - 20 mg

Dosage regimen

From 7.5 To 20 mg once every 7 day(s)

Detailed description

The usual dose is 7.5-15 mg once weekly. The planned weekly dose may be administered in three divided doses over 36 hours. The schedule may be adjusted gradually to achieve an optimal response but should not exceed a total weekly dose of 20 mg. Thereafter the dose should be reduced to the lowest possible effective dose which in most cases is achieved within 6 weeks.

Active ingredient

Methotrexate

Methotrexate (4-amino-10-methylfolic acid) is a folic acid antagonist which inhibits the reduction of folic acid and increase of tissue cells. Methotrexate enters the cell through an active transport mechanism of reduced folates. As a result of polyglutamation of methotrexate caused by the folylpolyglutamylate enzyme, the duration of the cytotoxic effect of the drug substance in the cell increases.

Read more about Methotrexate

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