HIV infection

Active Ingredient: Stavudine

Indication for Stavudine

Population group: only adults (18 - 65 years old)

Stavudine is indicated in combination with other antiretroviral medicinal products for the treatment of HIV infected adult patients and paediatric patients (over the age of 3 months) only when other antiretrovirals can not be used. The duration of therapy with stavudine should be limited to the shortest time possible.

For this indication, competent medicine agencies globally authorize below treatments:

60-80 mg in 2 divided doses daily

Route of admnistration

Oral

Defined daily dose

60 - 80 mg

Dosage regimen

From 30 To 40 mg 2 time(s) per day every day

Detailed description

Patient weight <60 kg: 30 mg twice daily (every 12 hours).

Patient weight ≥60 kg: 40 mg twice daily (every 12 hours).

Dosage considerations

For optimal absorption, stavudine should be taken on an empty stomach (i.e. at least 1 hour prior to meals) but, if this is not possible, it may be taken with a light meal. Stavudine may also be administered by carefully opening the hard capsule and mixing the contents with food.

Active ingredient

Stavudine

Stavudine, a thymidine analogue, is phosphorylated by cellular kinases to stavudine triphosphate which inhibits HIV reverse transcriptase by competing with the natural substrate, thymidine triphosphate. It also inhibits viral DNA synthesis by causing DNA chain termination due to a lack of the 3'-hydroxyl group necessary for DNA elongation. Cellular DNA polymerase γ is also sensitive to inhibition by stavudine triphosphate, while cellular polymerases α and β are inhibited at concentrations 4,000-fold and 40-fold higher, respectively, than that needed to inhibit HIV reverse transcriptase.

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