Stavudine Other names: Stavudine

Chemical formula: C₁₀H₁₂N₂O₄  Molecular mass: 224.213 g/mol  PubChem compound: 18283

Active ingredient description

Stavudine, a thymidine analogue, is phosphorylated by cellular kinases to stavudine triphosphate which inhibits HIV reverse transcriptase by competing with the natural substrate, thymidine triphosphate. It also inhibits viral DNA synthesis by causing DNA chain termination due to a lack of the 3'-hydroxyl group necessary for DNA elongation. Cellular DNA polymerase γ is also sensitive to inhibition by stavudine triphosphate, while cellular polymerases α and β are inhibited at concentrations 4,000-fold and 40-fold higher, respectively, than that needed to inhibit HIV reverse transcriptase.

Medicine classification

This medicinal substance has been classified in the anatomical therapeutic chemical (ATC) classification according to its main therapeutic use as follows:

ATC code Group title Classification
J05AF04 Stavudine J Antiinfectives for systemic use → J05 Antivirals for systemic use → J05A Direct acting antivirals → J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
Discover more medicines within J05AF04

Product monographs

Competent medicine agencies globally have authorized commercialization of this active ingredient according to these medication package inserts (MPIs):

Title Information Source Document Type  
ZERIT Powder for oral solution European Medicines Agency (EU) MPI, EU: SmPC
ZERIT Hard capsule European Medicines Agency (EU) MPI, EU: SmPC

Structural formula

Graphic representation of the active ingredient's molecular structure

External identifiers

CAS Substance: 3056-17-5
DrugBank Drug: DB00649
KEGG Drug: D00445
PubChem Compound: 18283
RxNorm Ingredient: 59763
SNOMED-CT Concept: 386895008
Stavudine (substance)
UNII Identifier: BO9LE4QFZF
STAVUDINE

Medicines

Stavudine is an active ingredient of these brands:

Brazil (BR)

Estonia (EE)

Ireland (IE)

Lithuania (LT)

Netherlands (NL)

Poland (PL)

Romania (RO)

South Africa (ZA)

Note the following: The list of brand names is continuously updated, and thus does not include the total of products circulating worldwide.

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