Chorea associated with Huntington's disease

Active Ingredient: Valbenazine

Indication for Valbenazine

Population group: only adults (18 years old or older)
Therapeutic intent: Curative procedure

For this indication, competent medicine agencies globally authorize below treatments:

40 mg once daily for 2 weeks, followed by 20 mg dose increments every 2 weeks to the recommended dosage of 80 mg once daily

For:

Dosage regimens

Oral, 40 milligrams valbenazine, once daily, over the duration of 2 weeks. Afterwards, oral, 60 milligrams valbenazine, once daily, over the duration of 2 weeks. Afterwards, oral, 80 milligrams valbenazine, once daily.

Detailed description

The initial dosage for valbenazine is 40 mg once daily. Increase the dose in 20 mg increments every two weeks to the recommended dosage of 80 mg once daily. A dosage of 40 mg or 60 mg once daily may be considered depending on response and tolerability.

Dosage considerations

Administer valbenazine with or without food.

Active ingredient

Valbenazine

The mechanism of action of valbenazine for the treatment of tardive dyskinesia and chorea in patients with Huntington’s disease is unclear, but is thought to be mediated through the reversible inhibition of vesicular monoamine transporter 2 (VMAT2), a transporter that regulates monoamine uptake from the cytoplasm to the synaptic vesicle for storage and release.

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