Active Ingredient: Bleomycin
Non-Hodgkin’s lymphoma of intermediate and high malignancy in adults.
For this indication, competent medicine agencies globally authorize below treatments:
Intramuscular
5,000 - 15,000 [iU] per m² of body surface area (BSA)
From 5,000 To 15,000 [iU] per m² of body surface area (BSA) once every 7 day(s)
When used alone, intramuscular or intravenous injection of 5-15 × 103 IU/m² BSA, once or twice a week, up to a cumulative total dose of 225 × 103 IU. Because of the possibility of anaphylactoid reactions, lymphoma patients should be treated with lower doses (for instance 2 × 103 IU) for the first two applications. If there are no acute reactions after 4 hours of observation, the normal dose schedule can be followed.
Dissolve the contents of a vial in 1-5 mL physiological saline solution. Since repeated i.m. injections at the same site can cause local discomfort, it is recommended to change the injection site regularly. In the event of excessive local discomfort, a local anaesthetic can be added to the injection solution, e.g. 1.5-2 mL lidocaine HCl 1%.
Intravenous
5,000 - 15,000 [iU] per m² of body surface area (BSA)
From 5,000 To 15,000 [iU] per m² of body surface area (BSA) once every 7 day(s)
When used alone, intramuscular or intravenous injection of 5-15 × 103 IU/m² BSA, once or twice a week, up to a cumulative total dose of 225 × 103 IU. Because of the possibility of anaphylactoid reactions, lymphoma patients should be treated with lower doses (for instance 2 × 103 IU) for the first two applications. If there are no acute reactions after 4 hours of observation, the normal dose schedule can be followed.
Dissolve the contents of a vial in 5-10 mL physiological saline solution and inject slowly over a period of 5-10 minutes. Fast bolus injections are to be avoided, because they lead to high intrapulmonary plasma concentrations, increasing the risk of lung damage.
Dissolve the contents of a vial in 200-1,000 mL physiological saline solution.
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