Tonic-clonic seizures (grand mal epilepsy), partial seizures

Active Ingredient: Phenytoin

Indication for Phenytoin

Population group: only infants (40 days - 1 year old) , children (1 year - 12 years old) , adolescents (12 years - 18 years old)

Control of tonic-clonic seizures (grand mal epilepsy), partial seizures (focal including temporal lobe) or a combination of these, and for the prevention and treatment of seizures occurring during or following neurosurgery and/or severe head injury.

For this indication, competent medicine agencies globally authorize below treatments:

4-8 mg/kg in 2 divided doses daily

Route of admnistration

Intravenous

Defined daily dose

4 - 8 mg per kg of body weight

Dosage regimen

From 2 To 4 mg per kg of body weight 2 time(s) per day every day

Detailed description

Initially, 5 mg/kg/day in two divided doses, with subsequent dosage individualised to a maximum of 300 mg daily. A recommended daily maintenance dosage is usually 4 mg/kg – 8 mg/kg.

4-8 mg/kg in 2 divided doses daily

Route of admnistration

Oral

Defined daily dose

3 - 4 mg per kg of body weight

Dosage regimen

From 1.5 To 2 mg per kg of body weight 2 time(s) per day every day

Detailed description

Initially, 5 mg/kg/day in two divided doses, with subsequent dosage individualised to a maximum of 300 mg daily. A recommended daily maintenance dosage is usually 4 mg/kg-8 mg/kg.

Active ingredient

Phenytoin

Phenytoin is effective in various animal models of generalised convulsive disorders, reasonably effective in models of partial seizures but relatively ineffective in models of myoclonic seizures. It appears to stabilise rather than raise the seizure threshold and prevents spread of seizure activity rather than abolish the primary focus of seizure discharge.

Read more about Phenytoin

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