Partial seizures

Active Ingredient: Pregabalin

Indication for Pregabalin

Population group: only adults (18 years old or older)

Pregabalin is indicated as adjunctive therapy in adults with partial seizures with or without secondary generalisation.

For this indication, competent medicine agencies globally authorize below treatments:

150-600 mg in 2 divided doses daily

Route of admnistration

Oral

Defined daily dose

150 - 600 mg

Dosage regimen

From 75 To 300 mg 2 time(s) per day every day

Loading dose

150 mg

Detailed description

Pregabalin treatment can be started with a dose of 150 mg per day given as two or three divided doses. Based on individual patient response and tolerability, the dose may be increased to 300 mg per day after 1 week. The maximum dose of 600 mg per day may be achieved after an additional week.

Discontinuation of pregabalin

In accordance with current clinical practice, if pregabalin has to be discontinued, it is recommended this should be done gradually over a minimum of 1 week independent of the indication.

Dosage considerations

It may be taken with or without food.

150-600 mg in 3 divided doses daily

Route of admnistration

Oral

Defined daily dose

150 - 600 mg

Dosage regimen

From 50 To 200 mg 3 time(s) per day every day

Loading dose

150 mg

Detailed description

Pregabalin treatment can be started with a dose of 150 mg per day given as two or three divided doses. Based on individual patient response and tolerability, the dose may be increased to 300 mg per day after 1 week. The maximum dose of 600 mg per day may be achieved after an additional week.

Discontinuation of pregabalin

In accordance with current clinical practice, if pregabalin has to be discontinued, it is recommended this should be done gradually over a minimum of 1 week independent of the indication.

Dosage considerations

It may be taken with or without food.

Active ingredient

Pregabalin

Pregabalin binds to an auxiliary subunit (α2-δ protein) of voltage-gated calcium channels in the central nervous system.

Read more about Pregabalin

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