Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2010 Publisher: Alliance Pharmaceuticals Ltd Avonbridge House 2 Bath Road Chippenham Wiltshire SN15 2BB UK
For the emergency treatment of acute poisoning and drug overdosage where substances such as those listed in section 5.1 have been ingested. The list is not exhaustive and Actidose-Aqua Advance may be of benefit following ingestion of many other toxins.
Also indicated for a limited number of systemic poisonings resulting from parenteral overdosage or when the ingested toxin has been totally absorbed. This usually involves repeated doses of Actidose-Aqua Advance to remove compounds which undergo enterohepatic recycling or which can diffuse into the gastrointestinal tract along a concentration gradient. Under these circumstances multiple doses of Actidose-Aqua Advance adsorb the toxin thereby preventing its reabsorption and increasing the concentration gradient in favour of further diffusion of the toxin into the gastrointestinal tract. Compounds most effectively transferred by this mechanism are lipophilic, uncharged and not excessively protein-bound. Examples of compounds which can be eliminated more rapidly by “gastrointestinal dialysis” in this way are phenobarbitone and theophylline.
The container should be shaken thoroughly prior to administration. If the dose of poison that has been ingested is known, a ratio of 10:1 (activated charcoal:toxin) may be used to determine the optimal dose of activated charcoal, subject to the limits of practicality. In the absence of any information regarding the amount of poison ingested, the following doses are recommended:
For single dose therapy, 50-100 grams of activated charcoal (240-480 ml) taken as soon as possible after ingestion of the poison.
For multiple dose therapy, 25-50 grams of activated charcoal (120-240 ml) every 4-6 hours.
For single dose therapy, 25-50 grams of activated charcoal (120-240 ml) taken as soon as possible after ingestion of the poison. For multiple dose therapy, the dose may be repeated every 4-6 hours.
For single dose therapy, 1 g or 5 ml per kg bodyweight taken as soon as possible after ingestion of the poison. For multiple dose therapy, the dose may be repeated every 4-6 hours.
When syrup of ipecac is used to produce emesis, administration of Actidose-Aqua Advance should be delayed until 30-60 minutes after vomiting has ceased. If gastric lavage is being used to facilitate stomach evacuation a single dose of Actidose-Aqua Advance may be administered early in the procedure. This has the advantage of prompt administration of activated charcoal, but the gastric lavage returns will be black which may make it difficult to evaluate what the patient ingested by visual examination.
Actidose-Aqua Advance may be effective even when several hours have elapsed after ingestion of the poison if gastrointestinal motility is reduced by the toxin or if the drug is subject to enterohepatic or enteroenteric recycling.
Actidose-Aqua Advance is well tolerated and due to its lack of toxicity overdosage requiring treatment is unlikely. A laxative may be administered to enhance elimination of the product.
Two years.
Store at 15 – 30°C. Do not refrigerate.
Shake well before use.
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