Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2011 Publisher: CHEPLAPHARM Arzneimettel GmbH Bahnhofstrasse 1A D-17498 Mesekenhagen Germany
Clomethiazole is pharmacologically distinct from both the benzodiazepines and the barbiturates.
Clomethiazole has sedative, muscle relaxant and anticonvulsant properties. It is used for hypnosis in elderly and institutionalised patients, for preanaesthetic sedation and especially in the management of withdrawal from ethanol. Given alone its effects on respiration are slight and the therapeutic index high.
Clomethiazole has a short half-life, low oral bioavailability, high plasma clearance and shows no evidence of accumulation or altered pharmacokinetics after repeated dosage. It is excreted in urine after extensive metabolism in the liver. The rate of elimination is decreased by about 30% in liver cirrhosis.
Extensive clinical use and experience with clomethiazole has provided a well established safety profile for this drug.
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