Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2012 Publisher: Pharmacia Limited Ramsgate Road Sandwich Kent CT13 9NJ UK
Hydrocortisone sodium succinate has the same metabolic and anti-inflammatory actions as hydrocortisone. It is a glucocorticosteroid. Used in pharmacological doses, its actions supress the clinical manifestations of disease in a wide range of disorders.
Twelve normal subjects received 100, 200 or 400 mg Solu-Cortef intravenously. Radio-immunoassay results were as follows:-
| DOSE (mg) | CMAX (mcg/100 ml) | TMAX (hr) | 12-HR AUC (mG/100 ml x hr) |
|---|---|---|---|
| 100 | 132.3 | 0.35 | 418.0 |
| 200 | 231.8 | 0.25 | 680.0 |
| 400 | 629.8 | 0.37 | 1024.0 |
In another study, a 1 mg/kg i.m. dose of Solu-Cortef peaked in 30-60 minutes, with a plasma cmax of 80 mg/100 ml.
In analysing hydrocortisone metabolism, a 25 mg IV dose resulted in higher plasma concentrations in females than in males.
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