Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2010 Publisher: Wockhardt UK Ltd Ash Road North Wrexham LL13 9UF United Kingdom
The anti-inflammatory effect of Colchicine in acute gouty arthritis is selective for this disorder. Although its mode of action is not clearly understood, it is thought that Colchicine causes the inhibition of the migration of granulocytes into the inflamed area. This reduces the release of lactic acid and proinflammatory enzymes that occurs during phagocytosis and breaks the cycle that leads to the inflammatory response.
Colchicine is readily absorbed from the gastrointestinal tract and peak concentrations occur in plasma by half an hour to two hours.
The kidney, liver and the spleen also contain high concentrations of Colchicine, but it is apparently largely excluded from the heart, skeletal muscle and brain. It is partially deacetylated in the liver. Colchicine and its metabolites are excreted in the urine and faeces.
There are no pre-clinical data of relevance to the prescriber which are additional to those already included in other sections.
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