Source: FDA, National Drug Code (US) Revision Year: 2020
AGRYLIN (anagrelide hydrochloride) is a platelet-reducing agent. Its chemical name is 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazolin-2(3H)-one monohydrochloride monohydrate. The molecular formula is C10H7Cl2N3O∙HCl∙H2O which corresponds to a molecular weight of 310.55.
The structural formula is:
Anagrelide hydrochloride is an off-white powder. It is very slightly soluble in water and sparingly soluble in dimethyl sulfoxide and dimethylformamide.
AGRYLIN is supplied as capsules for oral administration, containing 0.5 mg of anagrelide (equivalent to 0.61 mg of anagrelide hydrochloride USP). The capsules also contain anhydrous lactose NF, crospovidone NF, lactose monohydrate NF, magnesium stearate NF, microcrystalline cellulose NF, and povidone NF as inactive ingredients. The capsule shell contains gelatin, titanium dioxide, and black iron oxide.
| Dosage Forms and Strengths |
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Capsules: White, opaque capsule, imprinted with " |
| How Supplied |
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AGRYLIN is available as: 0.5 mg, opaque, white capsules imprinted " Distributed by: Takeda Pharmaceuticals America, Inc., Lexington, MA 02421 |
| Drug | Countries | |
|---|---|---|
| AGRYLIN | Brazil, Canada, Hong Kong, Japan, New Zealand, Singapore, United States, South Africa |
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063" in black ink. Each capsule contains 0.5 mg anagrelide equivalent to 0.61 mg anagrelide hydrochloride USP.