Source: Υπουργείο Υγείας (CY) Revision Year: 2014 Publisher: MEDOCHEMIE LTD, 1-10 Constantinoupoleos street, 3011 Limassol, Cyprus
Pharmacotherapeutic group: Anxiolytics – Benzodiazepine derivatives
ATC code: N05BA08
Bromazepam is a psychotropic substance of the pyridylbenzodiazepine class and has anxiolytic properties. It binds to specific receptors in the central nervous system and particular peripheral organs. The central nervous system benzodiazepine receptors have a close functional connection with the receptors of the GABA-ergic transmitter system. Following binding to the benzodiazepine receptor the inhibitory effect of the GABA0ergic transmission is augmented by bromazepam.
Bromazepam is rapidly absorbed from the gastro-intestinal tract. Peak plasma concentration are usually reached within two hours of oral administration of bromazepam. The absolute (versus iv solution) and relative (versus oral solution) bioavailability of the tablet is 60% and 100% respectively.
On average 70% of bromazepam is bound to plasma proteins. The volume of distribution is 50 lts. Steady state plasma concentrations are reached in around five to nine days.
Bromazepam is metabolized in the liver. Quantitatively two metabolites predominate: 3 hydroxy-bromazepam and 2-(2-amino-5-bromo-3-hydroxybenzoyl) pyridine. Metabolites of bromazepam do not contribute significantly to the effects of the drug.
Bromazepam has an elimination half life of about 20 hours (between approximately 16 and 30 hours). The clearance is 40 ml/min.
The elimination half-life may be prolonged in elderly patients.
No further information of relevance to the prescriber.
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