Source: Υπουργείο Υγείας (CY) Revision Year: 2018 Publisher: Remedica Ltd, Aharnon Street, Limassol Industrial Estate, 3056 Limassol, Cyprus
Undesirable effects may be minimised by using the lowest effective dose for the shortest duration necessary to control symptoms (see section 4.4, Special warnings and precautions for use).
The usual total daily dosage is 1500 mg in divided doses.
NSAIDs should be used with particular caution in elderly patients who are more prone to adverse events, especially with long-term use. Therefore, the risks versus the benefits of chronic therapy in the elderly should be carefully considered. The lowest dose compatible with adequate safe clinical control should be employed (see section 4.4,
Special warnings and precautions for use). Treatment should be reviewed at regular intervals and discontinued if no benefit is seen or intolerance occurs.
Not recommended for children under 12 years of age.
Do not exceed the stated dose.
Alfoxan should be taken preferably with or after food.
Oral administration.
Gastric lavage in the conscious patient and intensive supportive therapy where necessary. Vital functions should be monitored and supported. Activated charcoal has been shown to be a powerful absorbent for mefenamic acid and its metabolites. Studies in experimental animals and humans have shown that a 5 to 1 ratio of charcoal to mefenamic acid results in considerable suppression of absorption of the drug. Haemodialysis is of little value since mefenamic acid and its metabolites are firmly bound to plasma proteins. Overdose has led to fatalities.
Mefenamic acid has a tendency to induce tonic-clonic (grand mal) convulsions in overdose. Acute renal failure and coma have been reported with mefenamic acid overdose. It is important that the recommended dose is not exceeded and the regime adhered to since some reports have involved daily dosage under 3 g.
5 years.
Store below 25°C, protected from light and moisture.
PVC/Aluminium blisters. Pack sizes of 20 and 100 film-coated tablets.
PP containers with PE closure. Pack sizes of 100 and 1000 film-coated tablets.
Not all pack sizes may be marketed.
No special requirements.
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