Source: Υπουργείο Υγείας (CY) Revision Year: 2018 Publisher: Medochemie Ltd, 1-10 Constantinoupoleos street, 3011 Limassol, Cyprus
Amben is indicated in the treatment of the following infections when due to susceptible micro-organisms:
500mg to 1g twice a day, depending upon the severity of infection.
Alternatively, in skin and soft tissue and uncomplicated urinary tract infections, 1g once a day.
In the treatment of beta-haemolytic streptococcal infections, Amben should be administered for at least 10 days.
As for adults.
Children under 1 year: 25mg/kg daily in divided doses.
Children 1-6 years: 250mg twice a day.
Children over 6 years: 500mg twice a day.
No specific dosage recommendations or precautions for use in the elderly except to monitor those patients with impaired renal function.
In patients with renal impairment, the dosage should be adjusted according to creatinine clearance rates to prevent drug accumulation and serum levels should be monitored.
A modified dosage schedule is unnecessary in patients with creatinine clearance rates of greater than 50ml/min. In those patients with creatinine clearance rates of 50ml/min or less, the following dosage schedule is recommended as a guideline, based upon the creatinine clearance rate (ml/min: 1.73 m²).
Patients with renal insufficiency may be treated with an initial dose of 500mg to 1000mg of Amben. Subsequent doses may be administered according to the following table:
| Creatinine Clearance | Dose | Dose Interval |
|---|---|---|
| 0-10 ml/min/1.73 m² | 500-1000 mg | 36 hrs |
| 11-25 ml/min/1.73 m² | 500-1000 mg | 24 hrs |
| 26-50 ml/min/1.73 m² | 500-1000 mg | 12 hrs |
Amben can be removed from the body by haemodialysis.
Oral administration.
The bioavailability and consequent chemotherapeutic effects of cefadroxil are unaffected by food. It may, therefore, be taken with meals or on an empty stomach.
Ingestion of <250 mg/kg in children less than six years of age was not associated with significant outcomes.
The patient should be observed and treated symptomatically. For amounts >250 mg/kg gastric lavage or stimulation of vomiting is appropriate.
3 years.
Once reconstituted the mixture has 7 days validity at a temperature not exceeding 25°C and 14 days at 4°C (in refrigerator).
Store below 25°C.
For storage conditions after reconstitution of the medicinal product, see section 6.3.
Pack sizes of 100 ml & 60 ml in amber glass bottles are available.
Not all pack sizes may be marketed.
No special requirements for disposal.
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