Revision Year: 2011 Publisher: DR. FRANZ KÖHLER CHEMIE GMBH, Werner-von-Siemens-Str. 22-28, D-64625 Bensheim, Telephone 0 62 51/1083-0, Telefax 0 62 51 / 1083-146, E-Mail: info@koehler-chemie.de
For the treatment of postoperative disorders:
As antidote and/or antagonist in case of intoxication with and/or overdose of:
Infants: Start with a low dose of 0.5 mg of physostigmine salicylate administered intravenously or intramuscularly, repeat this dose every 5 minutes up to the overall dose of 2 mg, as long as the toxic, anticholinergic symptoms continue to persist and no cholinergic symptoms occur.
Slowly inject 0.04 mg/kg bodyweight (2 mg) of physostigmine salicylate either intravenously or intramuscularly and subsequently inject 1-4 mg every 20 minutes. Repeat the effective dose if the intoxication symptoms occur again, possibly also in the form of a continuous infusion.
Slowly inject physostigmine intravenously at a dose of 0.04 mg/kg bodyweight (approx. 1 mg/min), the max. individual dose is 2 mg. In case of insufficient effect, make subsequent injections after 5 to 20 minutes at the earliest, after a positive evaluation of the effect of the first injection.
Intravenously, intramuscularly or as brief infusion in 50 ml physiological isotonic saline solution over 10-15 minutes. A general criterion for adequate physostigmine dosing is the recognizable recovery of mental abilities and responsiveness (e.g. specifying name, address, date).
Overdose of Anticholium can cause bradycardia, hypersalivation, vomiting and generalized tonic-clonic seizures. Patients should be closely monitored by ECG. Intravenous administration of atropine up to normalization of the symptoms. Normally, half the amount of the administered physostigmine salicylate is sufficient. In case of intoxication, measures are to be started immediately to prevent absorption (such as gastric lavage, administration of activated charcoal and laxatives).
Shelf life in undamaged ampoules: 3 years.
The infusion solution should be used immediately after preparation.
Do not use the medicinal product after the expiry date stated on the pack.
Do not store above 25°C, store in the outer packaging, protected from light.
5 ml ampoules in packs containing 1 to 5 ampoules.
© All content on this website, including data entry, data processing, decision support tools, "RxReasoner" logo and graphics, is the intellectual property of RxReasoner and is protected by copyright laws. Unauthorized reproduction or distribution of any part of this content without explicit written permission from RxReasoner is strictly prohibited. Any third-party content used on this site is acknowledged and utilized under fair use principles.
