Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2016 Publisher: Wockhardt UK Ltd, Ash Road North, Wrexham, LL13 9UF
Atropine is an antimuscarinic agent. These substances are competitive inhibitors of acetylcholine at muscarinic receptors of autonomic effector sites with parasympathetic innervation.
Atropine is readily absorbed from the gastro-intestinal tract and mucous membranes. It is absorbed from the eye and to a lesser extent through intact skin.
It is rapidly cleared from the blood and is distributed through the body, crossing the blood-brain barrier. It is completely metabolised in the liver and is excreted in the urine as unchanged drug and metabolites.
There are no preclinical data of relevance to the prescriber which are additional to those already included in other sections.
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