Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2019 Publisher: Bray Group Ltd, 1 Regal Way, Faringdon, Oxfordshire, SN7 7BX
Pharmacotherapeutic group: silver compounds
ATC code: D08AL01
Silver nitrate acts as a caustic to remove unwanted tissue and destroy warts, verrucae and other small skin growths.
Absorption of silver nitrate is negligible via intact skin, and poor through most mucus membranes. It is known to be absorbed more efficiently via the gastrointestinal tract. The nitrate ion, produced in some instances by the action of nitrate-reducing bacteria on the substance from open wounds, etc, may give rise to methaemoglobinaemia, in extreme cases especially if large quantities of the product are used.
Silver has no known physiological function. This substance is biologically very refractory and is metabolised with difficulty. Any sizeable quantities that are absorbed later redistribute, mainly as deposits of silver metal and insoluble compounds, about the various organs of the body, principally within the connective tissues.
Accumulation is especially predominant within the skin and mucous membranes.
No data are available.
Topically applied silver nitrate is generally shed, eventually, externally from the original site of topical administration by desquamation. Systemic excretion is very slow and is reported to be almost exclusively faecal.
No data are available.
No data are available.
There are no preclinical safety data of significance to the prescriber which are not already included in the SPC.
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