Source: Health Products Regulatory Authority (ZA) Revision Year: 2017 Publisher: PHARMACARE LIMITED, Healthcare Park, Woodlands Drive, Woodmead 2191
BETADEXAMINE is a combination of betamethasone and dexchlorpheniramine and has antihistaminic and anti-inflammatory properties.
Betamethasone 0,25 mg is therapeutically equivalent to 1,6 mg of prednisone and has a pharmacological half-life of 5 to 6 hours but a biological active half-life of 36 to 72 hours. After oral administration, it is 72% bioavailable. Betamethasone has a slightly less mineralocorticoid (salt retention) effect.
Dexchlorpheniramine has a mean half-life of 30 hours (shorter in children) and after oral administration it is 25 to 50% bioavailable.
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