Source: Medicines Authority (MT) Revision Year: 2013 Publisher: J. Uriach & Cía. S.A., Av. Camí Reial 51-57, 08184 Palau-solità i Plegamans, Barcelona, Spain
Dimenhydrinate, an antihistamine derived from ethanolamine, is an equimolecular complex of diphenhydramine with 8-chlorotheophylline that acts by blocking the H1-receptors of histamine, impeding the propagation of emetogenic afferent impulses in the vestibular nuclei. It also interferes with the integration of such impulses in the nucleus of the solitary tract. In addition to this action, dimenhydrinate has peripheral anticholinergic properties and therefore, inhibits the manifestations of hypersecretion and gastric hypermotility. It also produces sedative effects that help alleviate the symptoms of kinetosis.
Dimenhydrinate is readily absorbed following oral administration, with a tmax of 2 hours. The antiemetic effect occurs 15 to 30 minutes after oral administration. Its action lasts from 3 to 6 hours.
Antihistamines are widely distributed in the body. It crosses the placenta and small amounts are excreted in breast milk. Dimenhydrinate is extensively metabolised in the liver and rapidly excreted in urine in its metabolised form.
The safety of this product is high and does not indicate the need to cite such studies.
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