BIOFLOR Capsule, hard Ref.[28145] Active ingredients: Saccharomyces boulardii

Source: Υπουργείο Υγείας (CY) Revision Year: 2021 Publisher: BIOCODEX, 7 avenue Gallieni, 94250 Gentilly, France

5.1. Pharmacodynamic properties

During transit under its viable form in the digestive tract, Saccharomyces boulardii CNCM I-745 exerts biological actions which are similar to the protective properties of the normal intestinal flora.

The principal modes of action of Saccharomyces boulardii CNCM I-745 in prevention and treatment of diarrhoeal syndromes are:

inhibition of pathogenic effects of certain micro-organisms and/or their toxins especially Clostridium difficile, principal causative organism of antibiotic-associated diarrhoea, and Vibrio cholerae, typical of the toxin-producing bacteria responsible for secretory diarrhoea;
trophic and immunostimulant effects on the intestinal tract involving notably a significant increase in the total and specific activity of the intestinal disaccharidases (sucrase, maltase and lactase), and a marked increase in secretory IgA concentrations in the intestinal fluid.

5.2. Pharmacokinetic properties

After repeated oral doses, Saccharomyces boulardii CNCM I-745 transits in the digestive tract without colonizing it, rapidly attaining significant intestinal concentrations which are maintained at a constant level throughout the administration period.

Saccharomyces boulardii CNCM I-745 is no longer present in the stools 2 to 5 days after discontinuation of treatment.

5.3. Preclinical safety data

None.

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