Source: Medicines & Healthcare Products Regulatory Agency (GB) Revision Year: 2020 Publisher: The Boots Company PLC, 1 Thane Road West, Nottingham, NG2 3AA
Pholcodine is a cough suppressant with mild sedative but little analgesic activity.
Maximum plasma concentrations are attained at 4 to 8 hours after an oral dose. The elimination half life ranges from 32 to 43 hours and volume of distribution is 30-49 l/kg.
Pholcodine is protein bound to the extent of 23.5%.
Pholcodine is metabolised in the liver but undergoes little conjugation.
There is little or no metabolism of pholcodine to morphine.
There are no preclinical data of relevance to the prescriber which are additional to that already included.
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